( Moscow May 2007 ISPPM Congress)
By Constantine Kafkalides,  MD
Head of aeromedical section of Hellenic Civil Aviation    
Address : SYROU 9  GLYFADA  ATHENS  166 74
TEL: +302108940579 mobile : +306972097960
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   The wider context of ideas of prenatal and perinatal medicine and psychology which some pioneers started in the 70’s, in which more and more people have been espousing since then, allows the formulation of some new although still tentative conjectures in medicine and some proposals about how eventually confirm them or refuse them.
      I would like to discuss with you a group of diseases, the autoimmune diseases and the mechanism through which probably is explained the origin of their pathogenesis.    
     Let’s, point out at first the main topics of my speech.
1) How does the immune system function.    
2) What is autoimmunity. 
3) Cross-correlation of autoimmune diseases with engraved  
     memories during  intrauterine life, according to Dr  
     Athanassios Kafkalides research work.(1)    
    4) During the 9 months of pregnancy, is the future mother 
         capable with certain process, to modify the embryo’s 
         cells that could lead to autoimmune diseases?
      5) Which statistical indications, lead us to the above cross- 
      6) Proposal for two bio molecular mechanisms. 
1. Athanassios Kafkalides, MD  The Knowledge of the Womb, Autopsychognosia With Psychedelic Drugs, Authorhouse, USA, 2005
 7) How does the mother’s nervous system communicate 
     with her embryo /foetus?   
     Introduction, of specific group of neuropeptides.        . 
8)     Do the autoimmune diseases constitute event of more 
     general disturbance that leads to loss of identity of the   
  9) Three clues on cellular memory and cellular consciousness.  10) When does a healthy cell decide to die? 
11) Under which triggering conditions, does the cell relives 
      the sense of death and is led to self-destruction?             12)        
      An alternative way to commit suicide. 
13) Why don't all of us manifest autoimmune diseases?           14) Which sample of the population is at risk to manifest 
          autoimmune diseases?
     In order to comprehend autoimmune diseases let’s remember how the immune system functions. This is composed by  groups of cells able to destroy almost any infectious intruder in our organism, even cancer cells at their early creation. These groups of cells have the ability to recognize if their objective is the healthy organism or not. Each healthy cell is characterized by the ability to declare its identity to the immune system (IS), escaping the danger to be destroyed. In autoimmune diseases, antibodies produced by the immune system (the so called autoantibodies) are turned adversely against healthy cells of the organism himself! It is very important to point out that many studies have established the routes by which the immune and central nervous (CNS) systems communicate. The CNS regulates the immune system through both neuroendocrine and neuronal pathways.
          Rheumatoid arthritis, Sjögren syndrome, Lupus erythematosus, valve-diseases of the heart, Insulin deficiency type II, thyroiditis Hashimoto, Gravis disease, haemolytic anaemia, multiple sclerosis, Chron disease,  are few of the 80 up to now in total, diagnosed autoimmune diseases.
  5% to 8% percent of the world population suffers from autoimmune diseases. Many factors have been accused of being involved in the pathogenesis of the above-mentioned entities such us, environmental, genetics, hormonal and psychological. 
 1) A research carried out in Denmark, showed that 3,467 over 7,704 (45%) persons with diagnosed schizophrenia, from 1981 to 1998, were associated with a history of autoimmune disease.(2)
 2) At least 70% of persons with autoimmune diseases are related to a sort of psychological disorder (3)          
(Internal medicine clinic at University of Yannina Greece remarks by assistant prof.  V.Voulgari)
 3)Mood disorders often are associated with thyroid dysregulations, particularly depressions with autoimmune thyroiditis.(4)
  The  conclusions of these research group argue that psychiatric disorder is a result of the autoimmune disease!
  For this specific category of diseases, we will see if we can connect them to fundamental traces of memory, engraved in the human nervous system, as they are revealed, at the research work of Athanassios Kafkalides and few other contemporary psychiatrists, (Frank Lake Stanislav Groff ) ho  started in the 50s and 60s using psychotropic drugs like the psychedelic LSD-25, psylocybine and ketamine hydrochloride, in deep psychotherapy sessions. These researches led to findings, which related, serious psychiatric disorders of adult persons, like depression, neurosis, and psychosomatic reactions, to unpleasant intrauterine conditions 
According to the final evaluation of the findings through deep psychotherapy sessions, these persons, relived emotions, caused by stimuli emanating from the maternal body during their intrauterine life, emotional stimuli, which set into question the existence of the persons themselves  (unwanted/ rejected) or in some cases, opposed the identity of their own gender (rejected for their sex).
  We take this well-known category of illnesses the so-called autoimmune diseases and based on the history of   persons suffering from these diseases we cross correlate them to
psychiatric disorders. At this point can we assume, that at the stage of conception and the 9 months of gestation that followed, with certain neurobiochemical process on behalf of the mother
3.   Internal medicine clinic at University of Yannina Greece assistant prof.       
      V.Voulgari .
 4.  Department of Psychiatry and Psychology, University of Göttingen, Germany, were  
      evaluated between January 1994 and May    2000.
the intracellular substance was potentially modified and as a result autoimmune diseases occurred? 
       Specifically the 70% and the 45% of these two different research groups are statistically very powerful arguments in order to search the explanation of these two extreme situations of psychic and physical disorder.   
   On the one hand we have a disorder on cellular level and on the other hand psychic disorder and we assume that   these factors coexist.  Hence we should also have a certain cause and this cause must be so deep that influences the cell, the organism and the psychic sphere.
That common cause   must be deep in the cellular memory.  Are the two disorders due to a common cause, which is memories, engraved in to the nervous system from the intra-uterine emotional rejection according to Dr Athanasios Kafkalides findings?   
    A legitimate question is how an unformed yet nervous system, without being connected directly with the nervous system of the mother, can receive and store neuronic stimuli.
It is well known from neurophysiology that every activated neuron cell releases to blood stream large amounts of neuropeptides so, we can accept that the embryo/ foetus, has pre-perceptive capabilities which are probably the result of a bond formed between specific neuropeptides emanating from the mother’s nervous system (of low molecular weight so that they can penetrate the   blood placenta barrier) with specific receptors on the surface of its neuron cells. This may be proved by molecular biologists by detecting and identifying the above neuropeptides.
  Based on the above, could we say that whatever influences the psychic sphere and the body is this specific group of neuropeptides that have reached, at the fundamental stages of its development, the nervous system of the embryo/foetus? 
  From now on, we will consider the feeling of the maternal, rejection as the effect of a specific group of neuropeptides or “neuropeptidotoxins”, on the under developed nervous system of the embryo/foetus, even able to regulate genes . Therefore these 80 autoimmune entities are not illnesses but the manifestation of more general disturbance, which is the loss of identity on behalf the cells of the organism. This denaturation of the cells at the first stages of organism’s creation, is due to specific neuropeptides, which prevented the intracellular environment to follow the initial planning, modifying it in a negative way.  
About another biomolecular mechanism that I will describe, we will consider that each living cell dispose memory and some level of consciousness. Three indications advocate that cells dispose memory and a certain level of consciousness.
1) Autoimmunity its self . ( It is hard to accept that evolution of  millions of years, leads to such a gross negligence, on behalf the immune system, attacking healthy cells! ) 
2) Apoptoses or cell programmed death (CPD) as it is described in histopathology.
3) The testimony of a person who relived pre-conception   
     reactivation of memory as a sperm cell, during a deep 
     psychotherapy session with ketamine hydrochloride.
    Every healthy cell is characterized by the capacity to declare its identity to the immune system, escaping the danger to be destroyed, this same cell if it “wants” to die it has just to declare a false identity which can be regulated by the DNA inhibiting histocompatibility by adding a specific protein on its surface and thus immediately the immune system will undertake to destroy it on sight. Thus we have the genesis of the autoimmune disease.
   The question is when a healthy cell decides to die and as consequence the organism that up to this point was healthy, is suddenly disturbed in to disease. What commands does the cell obey in, destroying its self?
   Our aim is to set a frame of inquiry, about whether we must seek in what we called cellular memory, even memory registered during the first stages of embryogenesis, to see if we can consider it, the ultimate cause which is triggered randomly in time in a way analogous to the way a stroke of a perfume in to our nostrils take us way back in time.
Under certain conditions an adult person may have a reactivation of existential demise desires, as these were transmitted from the pregnant mother. These triggering conditions may be the loss of a beloved person (which is perceived as emotional rejection), an emotional rejection by the lover or the mistress or an   offence at school or work, or even a bankruptcy . 
Such fear inducing stimuli as the above, moving deeper in to the nervous system of the person, scans the mnemonic field and resonates to something similar, on a cellular level, all ready known, stored in there from the past. Thus, existential fear emerges unconsciously at all dimensions of his psychic sphere, influencing his/her internal stability by a self-destructive tendency, self-rejection and his/her relation with the external environment with a hostile or destructive behavior towards other human beings and the ecosystem. Under such conditions of emotional rejection, every cell relives the recollection of its demise (death) as it was presented to it on the first stage of its creation, something disturbing its harmonization with the natural environment as it was planned perhaps on the basis of an “initial programming” and then, the level of ‘consciousness’ of all living cells decides, its disengagement from matter, that holds pain, seeking liberation. 
        How can this liberation be achieved for the person? With a direct act like suicide, which is, the realization of the maternal desire of her embryo’s/ foetus, death or the extinguish of its gender, with more long term procedures of self destruction, when the person cannot overcome the instinct of self preservation, like alcohol, drugs, excessive speed or a slower death through a chronic and   degenerative disease.
  There are of course many other mechanisms that can lead to similar symptoms like the ones of autoimmunity, including drugs, but we will focus in these cases where an autoimmune manifestation, is related to the event of some kind of emotional   rejection which either emerged spontaneously from the unconscious or is emanated from the environment. 
    My conclusions are based on observations made on a small bat quiet representative sample of 33 persons with autoimmune diseases (9 children 22 women and 2 men) and with the completion of specific questionnaire addressed to mothers in existence of these persons, at the General Hospital, and the Paediatric clinic at University of Yannina between 1996 – 1998. 
 I will refer to two characteristic cases among others.
 A woman, of 38 years old, with systematic lupus erythimatosus and depression (with antinuclear antibodies of homogeneous type positive 1: 150 and peripheral oedemas, third in the order of birth, following two sisters. She confessed   to me that her mother hated her of not being a boy and she had frequent suicidal thoughts.
 A boy of 11 years old with haemolytic anaemia, he was hospitalised with 40.000 platelets. He had been hospitalised already twice in the past two years for the same haematological problem. Interviewing his mother I got very important information regarding the boy. He was the Benjamin among her children after 3 brothers and a sister, totally unwanted, by her and the father, due to financial problems at the time when she was pregnant. Important is her report that just before all three haemolytic crises he had returned from school very distressed because the schoolteacher offended him.
   Somebody could ask, almost all of us we go through periods of emotional conflicts, so why don’t we manifest autoimmune diseases? 
   This is probably happens to many of us under particular circumstances, but the disorder is probably inverted shortly, because either, the degree of existential rejection we carry within us is not so intense or we have found mechanisms of   compensation, through some form of activity, as artistic, scientific, business, religious, philosophical and others. 
   Which population sample is potentially in danger to manifest an autoimmune disease? Or to put it in another way which sample has the predisposition for such a case? The answer lies upon the investigation of the subject. All of us do not carry qualitatively the same psychic traumatic experiences. The traces of memory that will be awaken are something unknown as well as the time of their awakening. This depends upon the external environment and the stimuli, which the person receives. 
If extended epidemiological studies affirm the relation between autoimmune diseases and intrauterine rejection we have to seek methods for prevention. 
          Every future mother and her close environment must be informed by her obstetrician or a social worker trained in pre- and perinatal psychology for the serious responsibility they bear towards the embryo/foetus she carries for these nine months. 
       The embryo/ foetus at some future time will be incorporated in our society and it will be disastrous, if it carries within it, it’s existential self-demise.  Thus, either he/she will be motivated by a self destruction tactic with suicidal tendencies, use of narcotics (seeking for some peacefulness which was not offered by the mother at the time when it should be offered), by manifesting a disease, obeying subconsciously to the will of his mother wishing him dead, or he will spread pain and death all around him revenging for the pain he had felt (e.g. hooliganism, fascism ) and from which he has never been released, considering that so far he has not succeeded to  solve his existential  problems . 
The Knowledge of the Womb with Psychedelic Drugs,  Authorhouse USA 2005
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